The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene.
Immunogen Information
Immunogen
Fusion protein of human ITGB1BP1
Swissprot
O14713
Synonyms
BodeninDKFZp686K08158ICAP 1ICAP 1AICAP 1alphaICAP 1BICAP-1ICAP-1AICAP-1alphaICAP-1BICAP1ICAP1AICAP1BIntegrin beta 1 binding protein 1Integrin beta-1-binding protein 1Integrin cytoplasmic domain associated protein 1 alphaIntegrin cytoplasmi