The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains;ITIH2 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 2) is a Protein Coding gene. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is ITIH3.
Immunogen Information
Immunogen
Fusion protein of human ITIH2
Swissprot
P19823
Synonyms
AI747202H2PIGHEP2Inter alpha (globulin) inhibitor H2Inter alpha globulin inhibitor H2 polypeptideInter alpha trypsin inhibitor complex component IIInter alpha trypsin inhibitor heavy chain H2Inter-alpha-inhibitor heavy chain 2Inter-alpha-trypsin i