Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.
Immunogen Information
Immunogen
Synthetic peptide of human ITPR2
Swissprot
Q14571
Synonyms
45-trisphosphate receptorInositol 1 4 5 trisphosphate receptor type 2Inositol 145-trisphosphate receptor type 2Inositol 145 trisphosphate receptor type 2InsP3 R2InsP3R2IP3 R2IP3 receptorIP3 receptor isoform 2IP3R 2IP3R2ITPR 2Itpr2ITPR2Typ
Gene Accession
NP_002214
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4