KCNJ3 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD87471A
Western blot analysis of extracts of MCF7 cells using KCNJ3 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of MCF7 cells using KCNJ3 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of mouse brain using KCNJ3 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of mouse brain using KCNJ3 Polyclonal Antibody at 1:1000 dilution.
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Overview

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Product Name
KCNJ3 Polyclonal Antibody
Catalog Number
RD87471A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Immunogen Information

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Immunogen
A synthetic peptide of human KCNJ3
Gene ID
3760
Swissprot
P48549
Synonyms
KCNJ3GIRK1KGAKIR3.1
Calculated MW
16kDa/24kDa
Observed MW
25kDa

Applications

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Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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