The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human KCNQ4
Swissprot
P56696
Synonyms
DFNA 2DFNA2KCNQ 4Kcnq4KCNQ4KQT like 4KQT-like 4KV7.4Potassium channel KQT like 4Potassium channel subunit alpha KvLQT4Potassium voltage gated channel KQT like protein 4Potassium voltage gated channel KQT like subfamily member 4Potassium voltag
Calculated MW
77 kDa
Gene Accession
NP_004691
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:50-1:200
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4