KDM3B Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD78197A
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using KDM3B Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using KDM3B Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using KDM3B Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using KDM3B Polyclonal Antibody at dilution 1:50
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Overview

Circle
Product Name
KDM3B Polyclonal Antibody
Catalog Number
RD78197A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Immunogen Information

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Immunogen
Recombinant protein of human KDM3B
Swissprot
Q7LBC6
Synonyms
5qNCAC5orf7JHDM2BJmjC domain containing histone demethylation protein 2BJmjC domain-containing histone demethylation protein 2Bjmjd1bJumonji domain containing 1BJumonji domain containing protein 1BJumonji domain-containing protein 1BKDM3BKDM3BK
Gene Accession
BC001202

Applications

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Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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