KLHL3 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD266137A
Western blot analysis of extracts of various cell lines using KLHL3 Polyclonal Antibody at dilution of 1:3000.
Western blot analysis of extracts of various cell lines using KLHL3 Polyclonal Antibody at dilution of 1:3000.
Variation
Quantity
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Overview
Circle
Product Name
KLHL3 Polyclonal Antibody
Catalog Number
RD266137A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Circle
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Immunogen Information
Circle
Immunogen
Recombinant fusion protein of human KLHL3 (NP_059111.2).
Gene ID
26249
Swissprot
Q9UH77
Synonyms
KLHL3PHA2D
Calculated MW
55 kDa/61 kDa/64 kDa
Observed MW
75 kDa
Applications
Circle
Reactivity
Human,Mouse
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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