KNSTRN Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD87841A
Western blot analysis of extracts of various cell lines using KNSTRN Polyclonal Antibody at 1:1000 dilution.
Product Name
KNSTRN Polyclonal Antibody
Catalog Number
RD87841A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5-kinastrin (SKAP complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences.
Immunogen Information
Immunogen
Recombinant fusion protein of human KNSTRN
Gene ID
90417
Swissprot
Q9Y448
Synonyms
KNSTRNC15orf23HSD11SKAPTRAF4AF1
Calculated MW
5kDa/37kDa/51kDa/62kDa
Observed MW
63kDa
Applications
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas