LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits,which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to LDL Receptor
Swissprot
P01130,P35951,P35952
Synonyms
FHFHCLDL RLDL receptorLDLCQ2LdlrLDLRLow Density Lipoprotein ReceptorLow density lipoprotein receptor class A domain containing protein 3Low density lipoprotein receptor familial hypercholesterolemiaLow-density lipoprotein receptor
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:200-1:1000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4