The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
Immunogen Information
Immunogen
Recombinant protein of human LDOC1
Swissprot
O95751
Synonyms
BCUR1Breast cancer up regulated 1Breast cancer upregulated 1Gm366Ldoc1LDOC1Leucine zipper down regulated in cancer 1Leucine zipper protein down regulated in cancer cellsLeucine zipper protein down regulated in cancer cellsLeucine zipper protein d
Gene Accession
BC003104
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4