This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Immunogen Information
Immunogen
Recombinant fusion protein of human LRP1 (NP_002323.2).
Gene ID
4035
Swissprot
Q07954
Synonyms
LRP1A2MRAPOERAPRCD91IGFBP3RKPALRPLRP1ATGFBR5
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:50-1:100
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
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