This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.
Immunogen Information
Immunogen
Recombinant protein of human LZTFL1
Swissprot
Q9NQ48
Synonyms
5530402H04Rik6130400H19RikAI414725AW048545BBS17DKFZp686H2076FLJ36386Leucine zipper transcription factor like 1Leucine zipper transcription factor like protein 1Leucine zipper transcription factor-like protein 1LZTFL 1Lztfl1Lztfl1 leucine zippe
Calculated MW
35 kDa
Gene Accession
BC025988
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4