The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Immunogen Information
Immunogen
Synthetic peptide of human MANF
Swissprot
P55145
Synonyms
Arginine rich mutated in early stage tumorsArginine rich proteinArginine-rich proteinARMETARMET proteinARPManfMANFMesencephalic astrocyte derived neurotrophic factorMesencephalic astrocyte-derived neurotrophic factorMGC142148MGC142150Protein A
Gene Accession
NP_006001
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4