The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Immunogen Information
Immunogen
Recombinant protein of human MAP4K2
Swissprot
Q12851
Synonyms
B lymphocyte serine/threonine protein kinaseB lymphocyte serine/threonine-protein kinaseBL44GC kinaseGCKGerminal center kinasegerminal centre kinase (GC kinase)M4K2Map4k2MAPK/ERK kinase kinase kinase 2MEK kinase kinase 2MEKKK 2Mitogen activate
Calculated MW
92 kDa
Gene Accession
BC047865
Applications
Reactivity
Human,Mouse
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4