The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [
Immunogen Information
Immunogen
Synthetic peptide of human MAPK11
Swissprot
Q15759
Synonyms
Human p38Beta MAP kinase mRNA complete cdsMAP kinase 11MAP kinase p38 betaMAPK 11Mapk11Mitogen activated protein kinase 11Mitogen activated protein kinase p38 2Mitogen activated protein kinase p38 betaMitogen-activated protein kinase 11Mitogen-ac
Calculated MW
41 kDa
Gene Accession
NP_002742
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4