MARK1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD79143A
Immunohistochemistry of paraffin-embedded Human brain tissue using MARK1 Polyclonal Antibody at dilution 1:30
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MARK1 Polyclonal Antibody at dilution 1:30
Product Name
MARK1 Polyclonal Antibody
Catalog Number
RD79143A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The microtubule matrix within a cell plays a central role in intracellular transport, cell shape during differentiation and chromosome partitioning during mitosis. During these processes, microtubules transition rapidly between stable and dynamic states. MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart.
Immunogen Information
Immunogen
Synthetic peptide of human MARK1
Swissprot
Q9P0L2
Synonyms
KIAA1477MAP/microtubule affinity regulating kinase 1MAP/microtubule affinity-regulating kinase 1MARK 1MARKMark1MARK1MGC126512MGC126513Serine/threonine protein kinase MARK1Serine/threonine-protein kinase MARK1
Gene Accession
NP_061120
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas