MCM3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD70114A
Immunohistochemistry of paraffin-embedded Human lymph node using MCM3 Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human tonsil using MCM3 Polyclonal Antibody at dilution of 1:200.
Product Name
MCM3 Polyclonal Antibody
Catalog Number
RD70114A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant Human DNA replication licensing factor MCM3 protien
Swissprot
P25205
Synonyms
Cervical cancer proto oncogene 5DNA polymerase alpha holoenzyme associated P1HCC 5HCC5hRlf beta subunitHuman cervical cancer proto oncogene 5MCM 3MGC1157Minichromosome maintenance complex component 3P1 hP1 MCM3P1.hp102Replication licensing fa
Applications
Reactivity
Human
Tested Applications
WB,IHC
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
2 mg/mL
Storage Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas