The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Immunogen Information
Immunogen
Recombinant Human DNA replication licensing factor MCM7 protien
Swissprot
P33993
Synonyms
CDABP0042CDC 47CDC47CDC47 homologCdc47S. cerevisiaehomolog ofDNA replication licensing factor MCM7Homolog of S. cerevisiae Cdc47MCM 2MCM 7MCM2MCM2formerlyMcm7MCM7 minichromosome maintenance deficient 7MCM7_HUMANMinichromosome Maintaine
Applications
Reactivity
Human
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
2 mg/mL
Storage Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.