MDC1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76508A
Immunohistochemistry of paraffin-embedded Human brain tissue using MDC1 Polyclonal Antibody at dilution 1:80
Product Name
MDC1 Polyclonal Antibody
Catalog Number
RD76508A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Immunogen Information
Immunogen
Synthetic peptide of human MDC1
Swissprot
Q14676
Synonyms
Homologue to Drosophila photoreceptor protein calphotinMDC 1Mdc1MDC1Mediation of DNA damage checkpoint 1Mediator of DNA damage checkpoint 1Mediator of DNA damage checkpoint protein 1NFBD 1NFBD1Nuclear factor with BRCT domains 1Nuclear Factor wit
Gene Accession
NP_055456
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
1.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas