Mediator of RNA polymerase II transcription subunit 6is one of the subunits of theMediator complex. It is anenzymethat in humans is encoded by theMED6gene. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.