MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy. ItsDrosophilaand mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development . There are two MOB1 proteins in humans, MOB1α and MOB1β, that are encoded by two different genes but which have greater than 95% amino acid sequence identity.
Immunogen Information
Immunogen
Synthetic peptide of human MOB1A
Swissprot
Q9H8S9
Synonyms
B1Mps One Binder kinase activator like 1B (yeast)C2orf6Chromosome 2 open reading frame 6FLJ10788FLJ11595MATS1MOB kinase activator 1AMOB1Mob1 alphaMob1 homolog 1BMOB1 Mps One Binder homolog AMOB1 Mps One Binder kinase activator like 1BMob1AMO
Calculated MW
25 kDa
Gene Accession
NP_060691
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4