Mono-Methyl-P53 (Lys370) Monoclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD86238A
Immunohistochemistry of paraffin-embedded Human lung carcinoma tissue using P53 (Mono Methyl Lys370) Monoclonal Antibody at dilution of 1:500.
Immunohistochemistry of paraffin-embedded Human lung carcinoma tissue using P53 (Mono Methyl Lys370) Monoclonal Antibody at dilution of 1:500.
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Overview

Circle
Product Name
Mono-Methyl-P53 (Lys370) Monoclonal Antibody
Catalog Number
RD86238A
Clonality
Monoclonal
Purification Method
Protein A purification
Isotype
IgG
Host
Mouse

Background

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The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

Immunogen Information

Circle
Immunogen
Synthetic Peptide
Swissprot
P04637
Synonyms
Antigen NY-CO-13BCC7Cellular tumor antigen p53FLJ92943LFS1Mutant tumor protein 53p53p53 tumor suppressorP53Phosphoprotein p53Tp53Transformation related protein 53TRP53Tumor protein 53Tumor protein p53Tumor suppressor p53

Applications

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Reactivity
Human,Mouse,Rat
Tested Applications
IHC-p
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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