Maintenance of DNA sequences is necessary for vertebrates and other life. DNA is under constant stress by a plethora of DNA-damaging agents present in both the environment and within cells. The potentially deleterious effects of DNA lesions in cells are elegantly resolved by sophisticated DNA repair systems, including base excision repair (BER), nucleotide excision repair (NER) and DNA repair methyltransferase (MTase). Methylated bases, such as 3-methyladenine (3MeA) and 7-methylguanine (7MeG) can be formed by agents in the environment and by endogenous cellular processes. Consequently, in the absence of exposure to environmental agents, DNA methylation damage can be incurred on the genomic DNA of normal mammalian cells. DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged bases from DNA as the first step in restoring the sequence.
Immunogen Information
Immunogen
Recombinant protein of human MPG
Swissprot
P29372
Synonyms
3 alkyladenine DNA glycosylase3-alkyladenine DNA glycosylase3-methyladenine DNA glycosidase3MGAAGADPGAlkyladenine DNA glycosylaseanpgAPNGCRA36.1DNA 3 methyladenine glycosylaseDNA-3-methyladenine glycosylaseMDGMid1MpgN methylpurine DNA glyco
Calculated MW
32 kDa
Gene Accession
BC014991
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4