This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Immunogen Information
Immunogen
Recombinant protein of human MRE11A
Swissprot
P49959
Synonyms
AT like diseaseAtaxia telangiectasia disorder likeATLDDNA recombination and repair proteinDouble strand break repair protein MRE11ADouble-strand break repair protein MRE11Aendo/exonuclease Mre11HNGS1meiotic recombination (S. cerevisiae) 11 homolog
Gene Accession
NP_005582
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4