MSL2 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD87625A
Western blot analysis of extracts of various cell lines using MSL2 Polyclonal Antibody at 1:3000 dilution.
Variation
Quantity
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Overview
Product Name
MSL2 Polyclonal Antibody
Catalog Number
RD87625A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub, but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me and 'Lys-79' (H3K79me and leads to gene activation, including that of HOXA9 and MEIS1.
Immunogen Information
Immunogen
Recombinant fusion protein of human MSL2
Gene ID
55167
Swissprot
Q9HCI7
Synonyms
MSL2MSL-2MSL2L1RNF184
Calculated MW
113kDa/115kDa
Observed MW
115kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.