This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Immunogen Information
Immunogen
Recombinant protein of human MVP
Swissprot
Q14764
Synonyms
LRPLung resistance related proteinLung resistance-related proteinMajor vault proteinMajor vault proteinrathomolog ofMVPMVPtesticular secretory protein Li 30VAULT 1VAULT1
Calculated MW
99 kDa
Gene Accession
BC015623
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4