Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Immunogen Information
Immunogen
Synthetic peptide of human MYSM1
Swissprot
Q5VVJ2
Synonyms
2A-DUB2ADUBHistone H2A deubiquitinaseHistone H2A deubiquitinase MYSM1KIAA1915Myb like SWIRM and MPN domains 1Myb likeSWIRM and MPN domain containing proteinMyb likeSWIRM and MPN domains 1Myb-likeMyb-likeSWIRM and MPN domains 1MYSM 1mysm1MYS
Calculated MW
95 kDa
Gene Accession
NP_001078956
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4