The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human NAE1
Swissprot
Q13564
Synonyms
59 kDaA 116A10.1Amyloid beta precursor protein binding protein 1 59kDAmyloid beta precursor protein binding protein 1 59kDaAmyloid beta precursor protein binding protein 1Amyloid beta precursor protein binding protein 159 kDaAmyloid beta precursor
Calculated MW
60 kDa
Gene Accession
BC000480
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000
Concentration
0.1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4