This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
Immunogen Information
Immunogen
Synthetic peptide of human NCOR1
Swissprot
O75376
Synonyms
hN CoRhNCoRKIAA1047N CoRN Cor/SMRT corepressor Rip13N CoR1N-CoRN-CoR1NCOR 1NCoRNcor1NCOR1Nuclear receptor co repressor 1Nuclear receptor corepressor 1Retinoid X receptor interacting protein 13RIP13Rxrip13thyroid hormone and retinoic acid
Gene Accession
NP_006302
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4