NF1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD253528A
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using NF1 Polyclonal Antibody at dilution of 1:65(×200)
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using NF1 Polyclonal Antibody at dilution of 1:65(×200)
Product Name
NF1 Polyclonal Antibody
Catalog Number
RD253528A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.NF1 (Neurofibromin 1) is a Protein Coding gene. Diseases associated with NF1 include Neurofibromatosis-Noonan Syndrome and Neurofibromatosis, Type 1. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and RET signaling. GO annotations related to this gene include binding and phosphatidylcholine binding.
Immunogen Information
Immunogen
Synthetic peptide of human NF1
Swissprot
P21359
Synonyms
DKFZp686J1293FLJ21220Neurofibromatosis Noonan syndromeNeurofibromatosis related protein NF 1Neurofibromatosis related protein NF1neurofibromatosis type INeurofibromatosis-related protein NF-1Neurofibromin 1Neurofibromin truncatedNeurofibromin1NF
Gene Accession
NP000258
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:40-1:250, ELISA 1:500-1000
Concentration
1.7 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.