NF2 / Merlin Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD86690A
Western blotting with anti-NF2 polyclonal Antibody at dilution of 1:1000. Lane 1: Mouse brain lysates, lane 2: Rat brain lysate.
Western blot of PC-3 cell lysate with NF2 polyclonal antibody at 1:1000 dilution.
Variation
Quantity
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Overview
Product Name
NF2 / Merlin Polyclonal Antibody
Catalog Number
RD86690A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway,a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Immunogen Information
Immunogen
Recombinant Human NF2 protein expressed by E.coli.
Gene ID
4771
Swissprot
P35240
Synonyms
ACNBANFMerlinNeurofibromin 2neurofibromin 2 (merlin)NF2SCHSchwannomerlinSchwannomin
Calculated MW
15kDa
Observed MW
13kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:1000
Concentration
2.2mg/mL
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol,pH 7.4
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.