Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Immunogen Information
Immunogen
Recombinant Protein
Swissprot
Q15653
Synonyms
I kappa B betaI-kappa-B-betaIkappaBbetaIKB betaIkB-BIkB-betaIKBBIKBBIkBbetaNF kappa BIBNF-kappa-B inhibitor betaNF-kappa-BIBNfkbibThyroid receptor interacting protein 9Thyroid receptor-interacting protein 9TR interacting protein 9TR-intera
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC-p
Conjugation
Unconjugated
Dilution
IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4