Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.
Immunogen Information
Immunogen
Fusion protein of human NFS1
Swissprot
Q9Y697
Synonyms
Cysteine desulfuraseCysteine desulfurasemitochondrialHUSSY 08IscSmitochondrialNFS1NFS1 nitrogen fixation 1NFS1 nitrogen fixation 1 homolog (S. cerevisiae)NFS1NIFSnitrogen fixation 1 (S. cerevisiaehomolog)nitrogen fixation gene 1nitrogen-