This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
Immunogen Information
Immunogen
Synthetic peptide of human NKX2-1
Swissprot
P43699
Synonyms
AV026640BCHBenign choreaBHCHomeobox protein NK 2 homolog AHomeobox protein NK-2 homolog AHomeobox protein Nkx 2.1Homeobox protein Nkx-2.1Homeobox protein Nkx2.1NK 2NK 2 homolog ANK2NK2 homeobox 1NK2drosophilahomolog ofANK2.1mousehomolog
Calculated MW
42 kDa
Gene Accession
NP_001073136
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4