This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen Information
Immunogen
Synthetic peptide of human NLRP7
Swissprot
Q8WX94
Synonyms
CLR19.4FLJ94610HYDMMGC126470MGC126471NACHTleucine rich repeat and PYD containing 7NACHTLRR and PYD containing protein 7NACHTLRR and PYD domains containing protein 7NACHTLRR and PYD domains-containing protein 7NALP7NALP7NLR familypyrin doma
Gene Accession
NP_001120727
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4