This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Immunogen Information
Immunogen
Recombinant protein of human NME1
Swissprot
P15531
Synonyms
AWDAWDdrosophilahomolog ofGAADGranzyme A activated DNaseGranzyme A-activated DNaseGZMA activated DNaseMetastasis inhibition factor NM23NBNBSNDK ANDKANDKANDP kinase ANDPK-ANDPKANM23NM23 long variantincludednm23-H1NM23-M1NM23H1Binclud
Calculated MW
17 kDa
Gene Accession
BC000293
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4