This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
Immunogen Information
Immunogen
Synthetic peptide of human NOD1
Swissprot
Q9Y239
Synonyms
CARD 4CARD4Caspase recruitment domain 4Caspase recruitment domain containing protein 4Caspase recruitment domain family member 4Caspase recruitment domain protein 4Caspase recruitment domain-containing protein 4CLR 7.1CLR7.1NLR family CARD domain
Gene Accession
NP_006083
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4