This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.
Immunogen Information
Immunogen
Synthetic peptide of human NOD2
Swissprot
Q9HC29
Synonyms
ACUGArthrocutaneouveal granulomatosisBLAUCARD15Caspase recruitment domain familymember 15Caspase recruitment domain protein 15Caspase recruitment domain-containing protein 15CDCLR16.3IBD1Inflammatory bowel disease protein 1LRR containing prote
Gene Accession
NP_071445
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4