This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.
Immunogen Information
Immunogen
Recombinant protein of human NOL3
Swissprot
O60936
Synonyms
Apoptosis repressor with CARDARCMuscle enriched cytoplasmic proteinMuscle-enriched cytoplasmic proteinMYCMYPNol3NOL3NOPNop30Nucleolar protein 3 (apoptosis repressor with CARD domain)Nucleolar protein 3Nucleolar protein of 30 kDa
Gene Accession
BC012798
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4