NOX2/gp91phox Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD90091A
Western blot analysis of extracts of various cell lines using NOX2/gp91phox Polyclonal Antibody at 1:1000 dilution.
Product Name
NOX2/gp91phox Polyclonal Antibody
Catalog Number
RD90091A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Immunogen Information
Immunogen
A synthetic peptide of human NOX2/gp91phox
Gene ID
1536
Swissprot
P04839
Synonyms
AMCBX2CGDGP91-1GP91-PHOXGP91PHOXIMD34NOX2p91-PHOXCYBB
Calculated MW
65kDa/66kDa/67kDa
Observed MW
97-100KDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas