This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen Information
Immunogen
Synthetic peptide of human NQO1
Swissprot
P15559
Synonyms
AzoreductaseCytochrome b 5 reductaseDHQUDIA 4DIA4Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)Diaphorase (NADH/NADPH)Diaphorase 4Dioxin inducible 1DT diaphoraseDT-diaphoraseDTDMenadione reductaseNAD(P)H dehydrogenase [quinone] 1NAD(P)H
Calculated MW
27 kDa
Gene Accession
NP_001020604
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4