NUAK1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD78846A
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using NUAK1 Polyclonal Antibody at dilution 1:70
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using NUAK1 Polyclonal Antibody at dilution 1:70
Product Name
NUAK1 Polyclonal Antibody
Catalog Number
RD78846A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Immunogen Information
Immunogen
Synthetic peptide of human NUAK1
Swissprot
O60285
Synonyms
AMP activated protein kinase family member 5AMPK related protein kinase 5AMPK-related protein kinase 5NUAK family SNF1 like kinaseNUAK family SNF1-like kinase 1Nuak1NUAK1Omphalocele kinase 1Probable serine/threonine protein kinase KIAA0537
Gene Accession
NP_055655
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
1.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas