NUDT15 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Western blot analysis of extracts of various cell lines using NUDT15 Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human liver using NUDT15 Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human stomach using NUDT15 Polyclonal Antibody at dilution of 1:100 (40x lens).
Product Name
NUDT15 Polyclonal Antibody
Catalog Number
RD85047A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
Immunogen Information
Immunogen
Recombinant fusion protein of human NUDT15 (NP_060753.1).
Gene ID
55270
Swissprot
Q9NV35
Synonyms
NUDT15MTH2NUDT15D
Calculated MW
18 kDa
Observed MW
19 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000 IHC 1:50-1:100
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas