The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth.
Immunogen Information
Immunogen
Recombinant protein of human OTUB1
Swissprot
Q96FW1
Synonyms
Deubiquitinating enzyme OTUB1hOTU1HSPC263OTB1OTU domain containing ubiquitin aldehyde binding protein 1OTU domainubiquitin aldehyde binding 1OTU domain-containing Ubal-binding protein 1OTU domain-containing ubiquitin aldehyde-binding protein 1OTU
Calculated MW
31 kDa
Gene Accession
BC007519
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4