p70 S6 kinase alpha Monoclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD85624A
Immunohistochemistry of paraffin-embedded Human lung carcinoma tissue using p70 S6 kinase alpha Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using p70 S6 kinase alpha Monoclonal Antibody at dilution of 1:200.
Product Name
p70 S6 kinase alpha Monoclonal Antibody
Catalog Number
RD85624A
Clonality
Monoclonal
Purification Method
Protein A purification
Isotype
IgG
Host
Mouse
Background
P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Immunogen Information
Immunogen
Recombinant Protein of P70 S6 Kinase of RPS6KB1
Swissprot
P23443
Synonyms
70 kDa ribosomal protein S6 kinase 1KS6B1p70 alphaP70 beta 1p70 ribosomal S6 kinase alphap70 ribosomal S6 kinase beta 1p70 S6 kinase alphaP70 S6 Kinasep70 S6 kinasealpha 1p70 S6 kinasealpha 2p70 S6Kp70 S6K-alphap70 S6KAp70(S6K) alphap70(S6
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC-p
Conjugation
Unconjugated
Dilution
IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.