This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PADI4 plays a role in the epigenetics, the deimination of arginines on histones 3 and 4 can act antagonistically to arginine methylation. The protein may be found in oligomers and binds 5 calcium ions per subunit. It catalyses the reaction: Protein L-arginine + H2O = protein L-citrulline + NH3.
Immunogen Information
Immunogen
Fusion protein of human PADI4
Swissprot
Q9UM07
Synonyms
EC 3.5.3.15HL 60 PADHL-60 PADPAD 4PADPADI 4PADI 5PADI H proteinPadi4PADI4PADI5PDI 4PDI 5PDI4PDI5Peptidyl arginine deiminase type IVPeptidyl arginine deiminase type VPeptidylarginine deiminase IVProtein arginine deiminaseProtein arginine