This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human PAICS
Swissprot
P22234
Synonyms
ADE2ADE2H1AIR carboxylaseAIRCDKFZp781N1372MGC1343MGC5024Multifunctional protein ADE2Multifunctional protein ADE2H1PaicsPAISPhosphoribosylaminoimidazole carboxylasePhosphoribosylaminoimidazole carboxylasephosphoribosylaminoimidazole succinocar
Calculated MW
47 kDa
Gene Accession
BC010273
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4