PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
Immunogen Information
Immunogen
Synthetic peptide of human PAX2
Swissprot
Q02962
Synonyms
FSGS7Paired box 2Paired box gene 2paired box homeotic gene 2paired box protein 2Paired box protein Pax 2Paired box protein Pax-2Paired box protein Pax2PAPRSPax 2