PAX5 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD82838A
Western blot analysis of extracts of Raji cells using PAX5 Polyclonal Antibody at dilution of 1:3000.
Western blot analysis of extracts of Raji cells using PAX5 Polyclonal Antibody at dilution of 1:3000.
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Overview

Circle
Product Name
PAX5 Polyclonal Antibody
Catalog Number
RD82838A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human PAX5 (NP_057953.1).
Gene ID
5079
Swissprot
Q02548
Synonyms
PAX5ALL3BSAP
Calculated MW
31 kDa/32 kDa/34 kDa/35 kDa/37 kDa/38 kDa/42 kDa
Observed MW
42 kDa

Applications

Circle
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:1000-1:3000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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