The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined.
Immunogen Information
Immunogen
Fusion protein of human PBXIP1
Swissprot
Q96AQ6
Synonyms
4732463H20RikHematopoietic PBX interacting proteinHPIPMGC38361Pre B cell leukemia homeobox interacting protein 1RP11-307C12.2